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Stability of trianionic curcumin enhanced by gemini alkyl O-Glucosides and alkyl trimethyl ammonium halides mixed micelles A Physicochemical and engineering aspects

Feng, Jin, Wu, Shanshan, Wang, Hua, Liu, Songbai
Colloids and surfaces 2016 v.504 pp. 190-200
cetyltrimethylammonium bromide, curcumin, electrostatic interactions, fluorescence, halides, hydrophobicity, micelles
Improved capability to inhibit degradation of trianionic curcumin has been realized in this study. The interaction between trianionic curcumin (Cur³⁻) and gemini dodecyl or tetradecyl O-glucoside micelles, tetradecyltrimethylammonium chloride (TTAC) or hexadecyltrimethylammonium bromide (CTAB) micelles as well as gemini alkyl O-glucosides (AGs)/alkyl trimethyl ammonium halides mixed micelles have been characterized. It is demonstrated that Cur³⁻ cannot be incorporated into gemini AGs micelles since the lack of electrostatic attraction and degraded as rapidly as in aqueous phase. Cur³⁻ tend to reside at palisade layer − water interface of TTAC or CTAB micelles due to the strong electrostatic interaction while moderate electrostatic interaction allows Cur³⁻ to locate more deeply in the palisade layer of mixed micelles. Additionally, mixed micelles tend to form a more compact and hydrophobic palisade layer than pure TTAC and CTAB ones. These factors bring about enhanced fluorescence intensity and blue − shift of emission maxima, improved fluorescence anisotropy and quantum yield, as well as reduced decay rate of Cur³⁻ in mixed micelles than in pure TTAC and CTAB ones.