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Nano-hydroxyapatite/polyacrylamide composite hydrogels with high mechanical strengths and cell adhesion properties
- Zhiyong Li, Wenying Mi, Huiliang Wang, Yunlan Su, Changcheng He
- Colloids and Surfaces B: Biointerfaces 2014 v.123 pp. 959-964
- cell adhesion, crosslinking, gels, hydrocolloids, micelles, mixing, nanocomposites, polyacrylamide, tensile strength, tissue engineering
- Nano-hydroxyapatite/polyacrylamide composite hydrogels were successfully fabricated by physically mixing nano-hydroxyapatite (nHAp) particles into a peroxidized micelles initiated and cross-linked (pMIC) polyacrylamide (PAAm) hydrogel. The nanocomposite hydrogels exhibited excellent mechanical properties. The fracture tensile stresses of the gels were in the range of 0.21–0.86MPa and the fracture tensile strains were up to 30mm/mm, and the compressive strengths were up to 35.8MPa. Meanwhile the introduction of nHAp endowed the composite hydrogels with good cell adhesion properties. This nHAp/PAAm nanocomposite hydrogel is expected to find potential applications in tissue engineering.