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Potential extra-ribosomal functions of ribosomal proteins in Saccharomyces cerevisiae

Author:
Lu, Hui, Zhu, Yi-fei, Xiong, Juan, Wang, Rong, Jia, Zhengping
Source:
Microbiological research 2015 v.177 pp. 28-33
ISSN:
0944-5013
Subject:
DNA repair, Saccharomyces cerevisiae, biogenesis, longevity, messenger RNA, protein synthesis, ribosomal RNA, ribosomal proteins, ribosomes, transcription (genetics), translation (genetics)
Abstract:
Ribosomal proteins (RPs), are essential components of the ribosomes, the molecular machines that turn mRNA blueprints into proteins, as they serve to stabilize the structure of the rRNA, thus improving protein biosynthesis. In addition, growing evidence suggests that RPs can function in other cellular roles. In the present review, we summarize several potential extra-ribosomal functions of RPs in ribosomal biogenesis, transcription activity, translation process, DNA repair, replicative life span, adhesive growth, and morphological transformation in Saccharomyces cerevisiae. However, the future in-depth studies are needed to identify these novel secondary functions of RPs in S. cerevisiae.
Agid:
5532265