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Preparative chromatography and natural products discovery
- McChesney, James D, Rodenburg, Douglas L
- Current opinion in biotechnology 2014 v.25 pp. 111-113
- chromatography, economics, silica
- Methodology is reviewed which significantly enhances the economics and efficiency of larger scale preparative normal phase chromatography. Maintenance of hydration of the silica media and regeneration and re-equilibration of the column after each separation is demonstrated to allow repeated use of the column without loss of performance or requirement of repacking.