PubAg

Main content area

Kisspeptin regulates the somatic growth-related factors of the cinnamon clownfish Amphiprion melanopus Part A Molecular & integrative physiology

Author:
Kim, Na Na, Choi, Young-Ung, Park, Heung-Sik, Choi, Cheol Young
Source:
Comparative biochemistry and physiology 2015 v.179 pp. 17-24
ISSN:
1095-6433
Subject:
Amphiprion melanopus, brain, gene expression, insulin-like growth factor I, liver, melatonin, messenger RNA, pituitary gland, somatotropin
Abstract:
This study aimed to test the effects of kisspeptin (Kiss) on somatic growth in the cinnamon clownfish Amphiprion melanopus. We investigated the effects of Kiss treatment on the growth by measuring the mRNA expressions of the growth hormone (GH), insulin-like growth hormone factor (IGF-I), somatolactin (SL), and melatonin receptor (MT). The expression levels of GH and SL of the pituitary gland and IGF-I of the liver increased after Kiss treatment (in vivo and in vitro). In addition, the MT mRNA expression increased in the pituitary gland and brain after Kiss treatment (in vivo and in vitro). These results support the hypothesis that Kiss directly regulates the somatic growth-related factors, such as GH, SL, and MT, and IGF-I in the cinnamon clownfish. Further, injection of Kiss resulted in significantly higher levels of plasma melatonin than that in the control. We, therefore, conclude that Kiss plays a role in modulating growth and artificially induced rapid growth in cinnamon clownfish.
Agid:
5538723