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Contrasting effects of cold acclimation versus obesogenic diets on chemerin gene expression in brown and brite adipose tissues

Hansen, Ida R., Jansson, Kim M., Cannon, Barbara, Nedergaard, Jan
BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1691-1699
acclimation, adipocytes, autocrine signaling, brown adipose tissue, cafeteria foods, cell culture, cold, epididymis, gene expression, gene expression regulation, high fat diet, males, mice, muscles, obesogenic diet, signal peptide, white adipose tissue
Based on results from a signal sequence trap, we investigated chemerin gene expression in brown adipose tissue. Male NMRI mice were exposed to 30, 22 or 4°C for 3weeks, or were fed control (chow) diet, cafeteria diet or high-fat diet at thermoneutrality for the same time. In brown adipose tissue, cold acclimation strongly diminished chemerin gene expression, whereas obesogenic diets augmented expression. Qualitatively, changes in expression were paralleled in brite/beige adipose tissues (e.g. inguinal), whereas white adipose tissue (epididymal) and muscle did not react to these cues. Changes in tissue expression were not directly paralleled by alterations in plasma levels. Both these intact animal studies and brown adipocyte cell culture studies indicated that the gene expression regulation was not congruent with a sympathetic/adrenergic control. The data are discussed in relation to suggested endocrine, paracrine and autocrine effects of chemerin.