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Feline hippocampal and piriform lobe necrosis as a consequence of severe cluster seizures in two cats in Finland

Fors, Sara, Van Meervenne, Sofie, Jeserevics, Janis, Rakauskas, Mindaugas, Cizinauskas, Sigitas
Acta veterinaria scandinavica 2015 v.57 no.1 pp. 41
cats, etiology, hippocampus, histopathology, magnetic resonance imaging, necrosis, seizures, Finland
Feline hippocampal and piriform lobe necrosis (FHN) has been reported from several countries worldwide and is considered an important aetiology for feline epileptic seizures. The aetiology of FHN remains unclear, however it is suspected that FHN might occur secondary to intense epileptic activity as described in humans and dogs although this has not yet been documented in cats. The purpose of our report is to describe the first cases of FHN in Finland diagnosed by magnetic resonance imaging (MRI) and histopathology. The two cases we describe had a well documented history of pre-existing seizures with normal brain MRI at the onset of cluster seizures but MRI done when the cats exhibited clinical deterioration secondary to severe seizure activity, revealed lesions in the hippocampus and piriform lobes typical of FHN. Our report confirms that feline hippocampus and piriform lobe necrosis does occur in the Finnish cat population and should therefore be considered as a differential diagnosis in cats with seizures. In addition, the presentation, clinical findings, results of MRI and/or histopathology shows that cats may develop FHN secondary to severe seizure activity.