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Baseline susceptibility to alpha-cypermethrin in Lutzomyia longipalpis (Lutz & Neiva, 1912) from Lapinha Cave (Brazil)

Pessoa, Grasielle Caldas DÁvila, Lopes, Josiane Valadão, Rocha, Marília Fonseca, Pinheiro, Letícia C., Rosa, Aline Cristine Luiz, Michalsky, Érika Monteiro, Dias, Edelberto Santos
Parasites & vectors 2015 v.8 no.1 pp. 469
Lutzomyia longipalpis, bioassays, cypermethrin, insecticide resistance, lethal dose 50, mortality, socioeconomics, spraying, visceral leishmaniasis, Brazil
BACKGROUND: Given the increase in cases of visceral leishmaniasis in recent years, associated with the socio-economic impact of this disease, as well as the wide distribution of Lutzomyia longipalpis in Brazil and the likelihood that this vector may develop resistance to insecticides used for control, the Ministry of Health considers as crucial the creation of a network in order to study and monitor the resistance of this vector to insecticides used for control. In this sense, this study aimed: 1) to characterize the susceptibility of L. longipalpis from Lapinha Cave (Lagoa Santa, MG - Brazil) to Alfateck SC200 in field bioassays, and 2) to define the susceptibility baseline to alpha-cypermethrin in laboratory bioassays, checking the possibility of using it as susceptibility reference lineage (SRL). FINDINGS: The field bioassays revealed that the tested population was highly susceptible to alpha-cypermethrin in all time periods with high mortality (~100 %) in all treated surfaces before six months after spraying. In the laboratory bioassays, the studied population presented LD₅₀, LD₉₅ and LD₉₉ to 0.78013, 10.5580 and 31.067 mg/m², respectively. The slope was 1.454121. CONCLUSIONS: The studied population of L. longipalpis was considered as adequate for SRL according criterion recommended by Pan-American Health Organization and has proven susceptibility to tested insecticide in the field. One cannot rule out the possibility of finding populations of L. longipalpis more susceptible to alpha-cypermethrin; therefore, further research is necessary on other populations with potential use as a SRL.