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Effects of Dietary Exposure to Sulfamethazine on the Hematological Parameters and Hepatic Oxidative Stress Biomarkers in Nile Tilapia (Oreochromis niloticus)

Fernanda Garcia Sampaio, Maria Lídia Carra, Claudio Martin Jonsson, Vitoria Teodoro Gonçalves, Genoefa Dal’Bo, Kátia Santos Damacena Nunes, José Henrique Valim, Bruno Stéfano Lima Dallago, Sonia Claudia do Nascimento de Queiroz, Felix Guillermo Reyes Reyes
Bulletin of environmental contamination and toxicology 2016 v.97 no.4 pp. 528-535
Oreochromis niloticus, biomarkers, body weight, catalase, dietary exposure, fish, fish culture, glutathione transferase, hematologic tests, juveniles, lipid peroxidation, medicated feeds, oral administration, oxidative stress
Sulfamethazine (SMZ) is one of the most commonly used sulfonamide compounds in fish farming, and its physiological effects on fish are unknown. SMZ was administered to juvenile Nile tilapia (Oreochromis niloticus) at a dose level of 422 mg kg⁻¹ body weight, for a period of 11 days, via medicated feed. Fish were divided into two groups, the control group (CG) and the group fed with SMZ in feed. The administration of SMZ did not alter the erythrograms and leukograms of the Nile tilapia. The SMZ-fed group showed the same hepatic lipid peroxidation (LPO) concentration as the CG. Nonetheless, the oral administration of SMZ raised the hepatic catalase (CAT) and glutathione S-transferase (GST) activities, the increase probably being sufficient to prevent hepatic LPO production. The oral administration of SMZ affects the hepatic GST and CAT activities of Nile tilapia.