U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.


Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.


Main content area

Assessing the Effects of Amoxicillin on Antioxidant Enzyme Activities, Lipid Peroxidation and Protein Carbonyl Content in the Clam Ruditapes philippinarum and the Mussel Mytilus galloprovincialis

Valerio Matozzo, Margherita Battistara, Ilaria Marisa, Valeria Bertin, Alessandro Orsetti
Bulletin of environmental contamination and toxicology 2016 v.97 no.4 pp. 521-527
Mytilus galloprovincialis, Ruditapes philippinarum, amoxicillin, biomarkers, catalase, clams, enzyme activity, gills, lipid peroxidation, mussels, oxidative stress, superoxide dismutase
In this study, we evaluated the capability of amoxicillin (AMX)—one of the most widely used antibiotics worldwide—to induce oxidative stress in both gills and digestive gland from two bivalve species, the clam Ruditapes philippinarum and the mussel Mytilus galloprovincialis. Superoxide dismutase (SOD) and catalase (CAT) activities, as well as the lipid peroxidation levels (LPO) and protein carbonyl content (PCC), were measured in bivalves exposed to 100, 200 and 400 µg AMX/L for 1, 3 and 7 days. The results obtained demonstrated that AMX affected slightly biomarker responses of molluscs.