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Molecular epidemiology of J-subgroup avian leukosis virus isolated from meat-type chickens in southern China between 2013 and 2014

Author:
Lin, Wencheng, Li, Xinjian, Dai, Zhenkai, Zhang, Xinheng, Chang, Shuang, Zhao, Peng, Zhang, Huanmin, Chen, Feng, Xie, Qingmei
Source:
Archives of virology 2016 v.161 no.11 pp. 3039-3046
ISSN:
0304-8608
Subject:
Avian leukosis virus, broiler chickens, molecular epidemiology, phylogeny, viruses, China
Abstract:
Members of avian leukosis virus subgroup J (ALV-J) cause various diseases associated with tumor formation and decreased fertility, resulting in major economic losses in the poultry industry worldwide. To assess the status of ALV-J infection in meat-type chickens in southern China, the molecular epidemiology of ALV-J strains was investigated. A total of 265 clinical samples collected from southern China from 2013 to 2014 were investigated in this study for the presence of ALV-J, which resulted in 12 virus isolates. Phylogenetic analysis showed that 91.7 % (11/12) of the ALV-J isolates have possessed high homology to Chinese layer isolates and belong to one subgroup. One of the ALV isolates (designated GD1411-1) was relatively closely related to the ALV-J broiler isolates, indicating that the GD1411-1 isolate might be a transition strain. Several unique nucleotide substitutions in gp85 and the U3 region were detected in all 12 ALV-J isolates. This study provides some interesting information on the molecular characterization of ALV-J isolates. These findings will be beneficial for understanding of the pathogenic mechanism of ALV-J infection.
Agid:
5556726