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Interactome analysis brings splicing into focus
- Dominguez, Daniel, Burge, Christopher B.
- GenomeBiology.com 2015 v.16 no.1 pp. 135
- alternative splicing, messenger RNA, proteins, spliceosomes
- The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate or repress splicing.Please see related Research article: http://www.genomebiology.com/2015/16/1/119/abstract