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pH-Controlled Assembly of DNA Tiles
- Amodio, Alessia, Adedeji, Abimbola
Feyisara, Castronovo, Matteo, Franco, Elisa, Ricci, Francesco
- Journal of the American Chemical Society 2016 v.138 no.39 pp. 12735-12738
- DNA, DNA conformation, genetic markers, metabolism, nanomaterials, pH
- We demonstrate a strategy to trigger and finely control the assembly of supramolecular DNA nanostructures with pH. Control is achieved via a rationally designed strand displacement circuit that responds to pH and activates a downstream DNA tile self-assembly process. We observe that the DNA structures form under neutral/basic conditions, while the self-assembly process is suppressed under acidic conditions. The strategy presented here demonstrates a modular approach toward building systems capable of processing biochemical inputs and finely controlling the assembly of DNA-based nanostructures under isothermal conditions. In particular, the presented architecture is relevant for the development of complex DNA devices able to sense and respond to molecular markers associated with abnormal metabolism.