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Branch-Selective Hydroarylation: Iodoarene–Olefin Cross-Coupling
- Green, Samantha
A., Matos, Jeishla L. M., Yagi, Akiko, Shenvi, Ryan A.
- Journal of the American Chemical Society 2016 v.138 no.39 pp. 12779-12782
- chemical reactions, cobalt, hydrogen, nickel, olefin
- A combination of cobalt and nickel catalytic cycles enables a highly branch-selective (Markovnikov) olefin hydroarylation. Radical cyclization and ring scission experiments are consistent with hydrogen atom transfer (HAT) generation of a carbon-centered radical that leads to engagement of a nickel cycle.