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Four new taraxastane-type triterpenoic acids from Cirsium setosum
- Luan, Na, Wei, Wen-Di, Wang, Ali, Wu, Xiu-Li, Qi, Yan, Li, Jin-Jie, Zheng, Jian-Quan, Shang, Xiao-Ya
- Journal of Asian natural products research 2016 v.18 no.11 pp. 1015-1023
- Cirsium arvense, acids, animal ovaries, cytotoxicity, humans, inhibitory concentration 50, mass spectrometry, nuclear magnetic resonance spectroscopy, ovarian neoplasms, triterpenoids
- Four new taraxastane-type triterpenoids acids 3 β ,22 α -dihydroxy-20-taraxasten-30-oic acid (1), 3 β -hydroxy-22-oxo-20-taraxasten-30-oic acid (2), 3-oxo-22 α -hydroxy-20- taraxasten-30-oic acid (3), and 3β,19β-dihydroxy-20-taraxasten-30-oic acid (4) were isolated and characterized from Cirsium setosum (Willd.) MB. Their structures were determined by the combination of 1D and 2D NMR experiments (¹H- ¹HCOSY, HSQC, HMBC and ROESY) and mass spectrometry. Compound 2 exhibited potent selective cytotoxicity against human ovarian cancer cell line A2780 with an IC ₅₀ value of 3.9 μM.