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A new macrolactin antibiotic from deep sea-derived bacteria Bacillus subtilis B5

Author:
Li, Wei, Tang, Xi-Xiang, Yan, Xia, Wu, Zhen, Yi, Zhi-Wei, Fang, Mei-Juan, Su, Xin, Qiu, Ying-Kun
Source:
Natural product research 2016 v.30 no.24 pp. 2777-2782
ISSN:
1478-6427
Subject:
Bacillus subtilis, Glomerella cingulata, Pestalotiopsis, antibiotics, antifungal properties, fungi, marine sediments, nuclear magnetic resonance spectroscopy, tea, Pacific Ocean
Abstract:
A new macrolactin derivate, 7- O -2′ E -butenoyl macrolactin A (1), together with three known macrolactin compounds, macrolactin A (2), 7- O -malonyl macrolactin A (3) and 7- O -succinyl macrolactin A (4), was isolated from the bacterial strain Bacillus subtilis B5, which was isolated from the 3000 m deep sea sediment of the Southwest Pacific Ocean. The structures of the new compounds were assigned by spectroscopic methods including 1-D/2-D NMR and MS analysis techniques. Compounds 1 and 2 demonstrated antifungal activities against tea pathogenic fungi Pestalotiopsis theae and Colletotrichum gloeosporioides .
Agid:
5562131