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Subsets of ATP-sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression
- Bodenstine, Thomas M., Vaidya, Kedar S., Ismail, Aimen, Beck, Benjamin H., Diers, Anne R., Edmonds, Mick D., Kirsammer, Gina T., Landar, Aimee, Welch, Danny R.
- FEBS letters 2012 v.586 no.1 pp. 27
- adenosine triphosphate, antagonists, cell communication, cell lines, gap junctions, gene expression regulation, homeostasis, metabolites, metastasis, potassium channels, receptors
- Gap junctional intercellular communication (GJIC) regulates cellular homeostasis by propagating signaling molecules, exchanging cellular metabolites, and coupling electrical signals. In cancer, cells exhibit altered rates of GJIC which may play a role in neoplastic progression. KATP channels help maintain membrane polarity and linkages between KATP channel activity and rates of GJIC have been established. The mechanistic relationship has not been fully elucidated. We report the effects of treatment with multiple KATP antagonist compounds on GJIC in metastatic cell lines demonstrating an increase in communication rates following treatment with compounds possessing specificities towards the SUR2 subunit of KATP. These effects remained consistent using cell lines with different expression levels of SUR1 and SUR2, suggesting possible off target effects on GJIC by these compounds.