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One-pot synthesis of carbamates and thiocarbamates from Boc-protected amines

Author:
Kim, Hee-Kwon, Lee, Anna
Source:
Tetrahedron letters 2016 v.57 pp. 4890-4892
ISSN:
0040-4039
Subject:
alcohols, amines, chemical reactions, chemical structure, synthesis, thiocarbamates, thiols
Abstract:
A highly efficient one-pot procedure for the synthesis of carbamates and thiocarbamates has been described. In the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, the isocyanate intermediates were generated in situ for further reactions with alcohols and thiols to afford the desired carbamates and thiocarbamates in high yields.
Agid:
5566715