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One-pot synthesis of carbamates and thiocarbamates from Boc-protected amines
- Kim, Hee-Kwon, Lee, Anna
- Tetrahedron letters 2016 v.57 pp. 4890-4892
- alcohols, amines, chemical reactions, chemical structure, synthesis, thiocarbamates, thiols
- A highly efficient one-pot procedure for the synthesis of carbamates and thiocarbamates has been described. In the presence of 2-chloropyridine and trifluoromethanesulfonyl anhydride, the isocyanate intermediates were generated in situ for further reactions with alcohols and thiols to afford the desired carbamates and thiocarbamates in high yields.