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Environmental Metabolic Footprinting: A novel application to study the impact of a natural and a synthetic β-triketone herbicide in soil

Patil, Chandrashekhar, Calvayrac, Christophe, Zhou, Yuxiang, Romdhane, Sana, Salvia, Marie-Virginie, Cooper, Jean-Francois, Dayan, Franck E., Bertrand, Cédric
The Science of the total environment 2016 v.566-567 pp. 552-558
agrochemicals, biomarkers, metabolome, metabolomics, multivariate analysis, pollution, risk assessment, soil, soil ecology, sulcotrione
This study presents a novel approach for assessing the risk of agrochemicals in soil microcosms through the use of non-targeted metabolomics. The metabolome of treated soils was extracted and tested through LCMS profiling in order to generate an "Environmental Metabolic Footprint" (EMF). A dynamic characterization of pollution biomarkers was obtained through a multivariate statistical analysis of EMF data, where our results show the possible evolution towards a state of resilience. The EMF methodology was applied to two β-triketone herbicides in soil microcosms: one natural, leptospermone, and one synthetic, sulcotrione. In spite of a four-fold higher application dose, leptospermone exhibited a lower resilience time than did sulcotrione (ca. 30 days vs ca. 45 days respectively).