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p62 in Cancer: Signaling Adaptor Beyond Autophagy
- Moscat, Jorge, Karin, Michael, Diaz-Meco, Maria T.
- Cell 2016 v.167 pp. 606-609
- autophagy, epithelium, genes, proteins
- Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.