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p62 in Cancer: Signaling Adaptor Beyond Autophagy

Author:
Moscat, Jorge, Karin, Michael, Diaz-Meco, Maria T.
Source:
Cell 2016 v.167 pp. 606-609
ISSN:
0092-8674
Subject:
autophagy, epithelium, genes, proteins
Abstract:
Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.
Agid:
5568424