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The polysaccharide and low molecular weight components of Opuntia ficus indica cladodes: Structure and skin repairing properties

Author:
Di Lorenzo, Flaviana, Silipo, Alba, Molinaro, Antonio, Parrilli, Michelangelo, Schiraldi, Chiara, D’Agostino, Antonella, Izzo, Elisabetta, Rizza, Luisa, Bonina, Andrea, Bonina, Francesco, Lanzetta, Rosa
Source:
Carbohydrate polymers 2017 v.157 pp. 128-136
ISSN:
0144-8617
Subject:
Opuntia ficus-indica, cladodes, keratinocytes, lactic acid, mannitol, models, molecular weight, polymers, polysaccharides, tissue repair
Abstract:
The Opuntia ficus-indica multiple properties are reflected in the increasing interest of chemists in the identification of its natural components having pharmaceutical and/or cosmetical applications. Here we report the structural elucidation of Opuntia ficus-indica mucilage that highlighted the presence of components differing for their chemical nature and the molecular weight distribution. The high molecular weight components were identified as a linear galactan polymer and a highly branched xyloarabinan. The low molecular weight components were identified as lactic acid, D-mannitol, piscidic, eucomic and 2-hydroxy-4-(4′-hydroxyphenyl)-butanoic acids. A wound healing assay was performed in order to test the cicatrizing properties of the various components, highlighting the ability of these latter to fasten dermal regeneration using a simplified in vitro cellular model based on a scratched keratinocytes monolayer. The results showed that the whole Opuntia mucilage and the low molecular weight components are active in the wound repair.
Agid:
5569216