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Correlations of PTEN genetic polymorphisms with the risk of depression and depressive symptoms in a Chinese population

Author:
Liu, Lin-Jing, Zhu, Cheng, Tian, Hai-Jia, Zheng, Tian-Sheng, Ye, Min-Jie, Li, Hui
Source:
Gene 2016 v.595 no.1 pp. 77-82
ISSN:
0378-1119
Subject:
alleles, anxiety, genotype, mental depression, odds ratio, patients, polymerase chain reaction, regression analysis, relative risk, restriction fragment length polymorphism, risk factors, single nucleotide polymorphism
Abstract:
This study aimed to investigate the correlations of three common single nucleotide polymorphisms (SNPs) in the PTEN gene (rs701848 T>C, rs2735343 G>C and rs112025902 A>T) with the risk of depression and depressive symptoms in a Chinese population.From July 2011 to June 2013, a total of 384 patients with depression and 400 healthy individuals were included in this study. These SNPs in the PTEN gene were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing. The Hamilton Depression Rating Scale (HAMD) was used to evaluate the severity of depression.The C allele of rs701848, the C allele of rs2735343 and the T allele of rs112025902 were associated with an increased risk of depression (odds ratio [OR]=3.814, 95% CI: 3.093–4.703, P<0.001; OR=2.642, 95% CI: 2.152–3.242, P<0.001; OR=2.882, 95% CI: 2.347–3.539, P<0.001; respectively). Depression patients carrying C allele (TC+CC) of rs701848 and carrying T allele (AT+TT) of rs112025902 had higher HAMD total scores and HAMD anxiety factor scores than those carrying TT genotype of rs701848 and carrying AA genotype of rs112025902 (all P<0.05). Furthermore, depression patients carrying C allele (GC+CC) of rs2735343 had lower HAMD total scores and HAMD factors associated with depression scores than those carrying GG genotype (both P<0.05). Logistic regression analysis revealed that rs701848, rs2735343 and rs112025902 polymorphisms in the PTEN gene may be independent risk factors of depression (relative risk [RR]=1.807, 95% CI=1.023–3.193, P=0.042; RR=1.759, 95% CI=1.033–2.995, P=0.038; RR=1.646, 95% CI=1.018–2.663, P=0.042; respectively).Our findings provide evidence that rs701848, rs2735343 and rs112025902 polymorphisms in the PTEN gene may be correlated with the risk of depression and depressive symptoms in the Chinese population.
Agid:
5570951