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Bm86 midgut protein sequence variation in South Texas cattle fever ticks

Author:
Freeman, Jeanne M., Davey, Ronald B., Kappmeyer, Lowell S., Kammlah, Diane M., Olafson, Pia U.
Source:
Parasites & vectors 2010 v.3 no.101 pp. 1
ISSN:
1756-3305
Subject:
Boophilus annulatus, Boophilus microplus, Rhipicephalus, amino acid sequences, antigens, cattle, equine piroplasmosis, midgut, quarantine, recombinant vaccines, ticks, vector control, Australia, Cuba, Texas
Abstract:
Cattle fever ticks, Rhipicephalus (Boophilus) microplus and R. (B.) annulatus, vector bovine and equine babesiosis, and have significantly expanded beyond the permanent quarantine zone established in South Texas. Currently, there are no vaccines approved for use within the United States for controlling these vectors. Vaccines developed in Australia and Cuba based on the midgut antigen Bm86 have variable efficacy against cattle fever ticks. A possible explanation for this variation in vaccine efficacy is amino acid sequence divergence between the recombinant Bm86 vaccine component and native Bm86 expressed in ticks from different geographical regions of the world.
Agid:
55717
Handle:
10113/55717