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Helicobacter pylori CagI is associated with the stability of CagA

Author:
Wang, Hua, Yao, Yizheng, Ni, Bin, Shen, Yixin, Wang, Xiaochun, Shen, Hongxing, Shao, Shihe
Source:
Microbial pathogenesis 2016 v.99 pp. 130-134
ISSN:
0882-4010
Subject:
Helicobacter pylori, carcinogenesis, pathogenicity islands, proteins, secretion
Abstract:
The type Ⅳ secretion system (T4SS) of H. pylori encoded by cag pathogenicity island mediates the injection of the toxin CagA, which is considered as a paradigm for bacterial carcinogenesis. T4SS is generally composed of a set of proteins, the majority of which still remain unclear. In this study, we have identified CagI, one of the T4SS proteins, which interacted with CagA and played an important role for CagA stability.
Agid:
5572044