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Preparation and investigation of solid lipid nanoparticles for drug delivery A Physicochemical and engineering aspects

Author:
Kalaycioglu, Gokce Dicle, Aydogan, Nihal
Source:
Colloids and surfaces 2016 v.510 pp. 77-86
ISSN:
0927-7757
Subject:
butanol, drug carriers, drugs, emulsifiers, lithocholic acid, nanoparticles, particle size, polysorbates, stearic acid, surface area, zeta potential
Abstract:
Solid lipid nanoparticles (SLN), a promising drug delivery vehicle, offer an alternative system to traditional colloidal carriers. In our study 12 new SLN formulations were fabricated via the “microemulsion (ME) method”, each leading to a different SLN size and composition. This method is a relatively easy technique and involves biocompatible conditions. Stearic acid has been used as lipid material of which the ratio is kept under 4% to prevent particle growth. Particle size and surface properties of the synthesized SLNs were controlled using various combinations of emulsifiers such as lithocholic acid, Pluronic F127, Tween 20, lecithin and butanol. Furthermore, the mean size of the particles was adjusted by changing the ME:water ratio in the dilution step which is independent from composition. It was found that most of the SLNs were in the colloidal size range (below 100nm) and spherical in shape, which provides high surface area to exploit, as an alternative adsorptive drug carrier system. Also, the surface charge density values of SLNs were calculated by considering size and zeta potential values which then helps in understanding the surface potential of particles. MB was chosen as a model molecule and entrapped on the surface of SLNs after the preparation, to determine the loading capacities and release efficiencies. As such, SLNs have been successfully produced which have controllable drug entrapment efficiency and release capacity according to the chosen combination of emulsifiers and dilution ratio. Thus, this study contributes to the improvement of alternative drug delivery systems with biocompatible and stable newly formulated SLNs.
Agid:
5572709