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Assessment of antioxidant activity, lipid profile, general biochemical and immune system responses of Wistar rats fed with dairy dessert containing Lactobacillus acidophilus La-5

Moura, C.S., Lollo, P.C.B., Morato, P.N., Esmerino, E.A., Margalho, L.P., Santos-Junior, V.A., Coimbra, P.T., Cappato, L.P., Silva, M.C., Garcia-Gomes, A.S., Granato, D., Bolini, H.M. A., Sant'Ana, A.S., Cruz, A.G., Amaya-Farfan, Jaime
Food research international 2016 v.90 pp. 275-280
Lactobacillus acidophilus, alanine transaminase, albumins, antioxidant activity, antioxidants, aspartate transaminase, blood lipids, blood serum, desserts, gastrointestinal system, heat shock proteins, high density lipoprotein cholesterol, lipid composition, low density lipoprotein cholesterol, monocytes, neutrophils, probiotics, protein content, rats, triacylglycerols, viability
The viability and survival of Lactobacillus acidophilus La5 under in vitro simulated gastrointestinal in probiotic dairy dessert was assessed. In addition, the effects of regular consumption of the dessert (5g/day) on the lipid profile, immune system, and antioxidant/biochemical status of Wistar rats were also evaluated after 2weeks of treatment. Adequate counts of L. acidophilus La-5 were observed regards the viability and gastrointestinal conditions. The probiotic dairy dessert was efficient in reducing the LDL-cholesterol, triacylglycerol and increased the HDL-cholesterol in serum. Aspartate amino transferase, alanine aminotransferase, total protein, albumin, heat shock proteins, immune system responses, and blood-cells counts (monocyte, lymphocyte, neutrophil and leucocyte) were not affected (p>0.05) after 15days of treatment. Overall, the probiotic dairy dessert may be a viable alternative to enhance the blood lipid profile and could be used to improve the antioxidant defenses.