U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

Pathogenic infection confounds induction of the estrogenic biomarker vitellogenin in rainbow trout

Author:
Richard Burki, Aleksei Krasnov, Kathrin Bettge, Caird E Rexroad III, Sergej Afanasyev, Mia Antikainen, Patricia Burkhardt-Holm, Thomas Wahli, Helmut Segner
Source:
Environmental Toxicology and Chemistry 2012 v.31 no.10 pp. 2318-2323
ISSN:
0730-7268
Subject:
Oncorhynchus mykiss, biomarkers, estradiol, fish, fish health, messenger RNA, parasitism, pathogens, transcriptome, vitellogenin
Abstract:
To examine the behavior of the estrogenic biomarker vitellogenin (VTG) under the combined impact of estrogens and pathogens, parasite-infected or noninfected rainbow trout were exposed to two doses of 17 beta-estradiol (E2). Infected and E2-exposed fish showed significantly lower hepatic VTG mRNA levels than healthy fish. Transcriptome data suggest that this was due to energetic constraints. Reduced responsiveness of the VTG biomarker in parasitized fish might obscure detection of low-level field exposure.
Agid:
55780
Handle:
10113/55780