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p-Terphenyl Derivatives from the Endolichenic Fungus Floricola striata

Author:
Li, Wei, Gao, Wei, Zhang, Ming, Li, Yue-Lan, Li, Lin, Li, Xiao-Bin, Chang, Wen-Qiang, Zhao, Zun-Tian, Lou, Hong-Xiang
Source:
Journal of natural products 2016 v.79 no.9 pp. 2188-2194
ISSN:
1520-6025
Subject:
Candida albicans, X-ray diffraction, active ingredients, antifungal properties, cell membranes, chemical structure, fungi, nuclear magnetic resonance spectroscopy, spectral analysis
Abstract:
Ten new p-terphenyl derivatives, floricolins A–J (1–10), together with six known compounds (11–16), were isolated from the extract of the endolichenic fungus Floricola striata. Chemical structures of these compounds were elucidated using spectroscopic data (HRESIMS and NMR). Among them, 9 and 10 were enantiomeric mixtures, and their configurations were established by single-crystal X-ray diffraction analysis using Cu Kα radiation. Evaluation of the isolated compounds against Candida albicans revealed that the most active compound, 3 (MIC 8 μg/mL), exerted fungicidal action by destruction of the cell membrane.
Agid:
5578777