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Two New Steroidal Saponins with Antifungal Activity from Hosta plantaginea Rhizomes

Author:
Wang, Mengyue, Xu, Zihan, Peng, Ying, Zhong, Guoyue, Li, Xiaobo
Source:
Chemistry of natural compounds 2016 v.52 no.6 pp. 1047-1051
ISSN:
0009-3130
Subject:
Candida albicans, Hosta, antifungal properties, chemistry, fungi, minimum inhibitory concentration, ornamental plants, rhizomes, steroid saponins, traditional medicine
Abstract:
Two new steroidal saponins, (25R)-3β-hydroxy-5α-spirost-9-en-12-one 3-O-β-D-galactopyranoside (hostasaponin A, 1), and (25R)-2α,3β-dihydroxy-5α-spirost-12-one 3-O-β-D-galactopyranoside (hostasaponin B, 2), together with a new natural product, 2α,3β-dihydroxy-5α-pregn-16-en-20-one (3), were isolated from the rhizomes of Hosta plantaginea, a perennial herb used mainly as an ornamental plant and folk medicine for fungal infection and various inflammations. The active evaluation results showed that 1 and 2 possess potent inhibition activity against Candida albicans, with MIC values less than 20 μg/mL.
Agid:
5579247