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CD32b expression is down-regulated on double-negative memory B cells in patients with Hashimoto's thyroiditis

Liu, Yalei, Gong, Yan, Qu, Chenxue, Zhang, Yang, You, Ran, Yu, Nan, Lu, Guizhi, Huang, Youyuan, Zhang, Hong, Gao, Ying, Gao, Yanming, Guo, Xiaohui
Molecular and Cellular Endocrinology 2017 v.440 pp. 1-7
B-lymphocytes, humoral immunity, pathogenesis, patients, receptors
Inhibitory CD32b receptors on B cells are critical for humoral immunity. The humoral response plays a role in the pathogenesis of Hashimoto's thyroiditis (HT). This study aimed to investigate B cell subset distribution and CD32b expression within these subsets in HT patients. B cell subset distribution and CD32b expression were analyzed in 60 HT patients and 21 healthy donors. Subset distribution and CD32b expression following stimulation with α-Ig and α-CD40 were also assessed. The percentage of double-negative (DN) memory cells was increased in the HT patients, while the expression level of CD32b on DN memory cells was decreased. Redistribution of B cell subsets was detected in response to stimulation with α-Ig. In addition, the expression level of CD32b was reduced following α-CD40 stimulation. These results suggest that abnormal B cell subset distribution and decreased CD32b expression on DN memory cells might be involved in the pathogenesis of HT.