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CD32b expression is down-regulated on double-negative memory B cells in patients with Hashimoto's thyroiditis

Author:
Liu, Yalei, Gong, Yan, Qu, Chenxue, Zhang, Yang, You, Ran, Yu, Nan, Lu, Guizhi, Huang, Youyuan, Zhang, Hong, Gao, Ying, Gao, Yanming, Guo, Xiaohui
Source:
Molecular and Cellular Endocrinology 2017 v.440 pp. 1-7
ISSN:
0303-7207
Subject:
B-lymphocytes, humoral immunity, pathogenesis, patients, receptors
Abstract:
Inhibitory CD32b receptors on B cells are critical for humoral immunity. The humoral response plays a role in the pathogenesis of Hashimoto's thyroiditis (HT). This study aimed to investigate B cell subset distribution and CD32b expression within these subsets in HT patients. B cell subset distribution and CD32b expression were analyzed in 60 HT patients and 21 healthy donors. Subset distribution and CD32b expression following stimulation with α-Ig and α-CD40 were also assessed. The percentage of double-negative (DN) memory cells was increased in the HT patients, while the expression level of CD32b on DN memory cells was decreased. Redistribution of B cell subsets was detected in response to stimulation with α-Ig. In addition, the expression level of CD32b was reduced following α-CD40 stimulation. These results suggest that abnormal B cell subset distribution and decreased CD32b expression on DN memory cells might be involved in the pathogenesis of HT.
Agid:
5585290