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CD98 signals controlling tumorigenesis
- Ip, Hugh, Sethi, Tariq
- The international journal of biochemistry & cell biology 2016 v.81 pp. 148-150
- amino acids, carcinogenesis, integrins, neoplasms, plasma membrane, signal transduction, therapeutics
- CD98 is implicated in a large number of cancers. CD98 regulates amino acid transport and integrin signaling, which are key drivers in tumor progression. The light chain in the CD98 heterodimer functions as an amino acid exchanger. Alongside the light chain, the heavy chain forms a heterocomplex at the plasma membrane to mediate signaling pathways. In this article, we review various approaches to blocking CD98 activity, which may lead to novel opportunities in cancer therapeutics.