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Haematological changes in albino wister rats exposed to sub-chronic administration of sub-lethal doses of Zamitraz® (12.5% amitraz)

Omoja, Valentine Uneojo, Asuzu, Isaac Uzoma, Anika, Silvanus Maduka
Journal of applied animal research 2017 v.45 no.1 pp. 76-79
albino, amitraz, anemia, body weight, dose response, erythrocyte count, hematology, hemoglobin, leukocytes, males, pests, rats, reticulocytes
There is the need to investigate the toxicological potential of increasing doses of amitraz on the haematology as recent trend in development of resistance by pests may lead to increasing the quantity of amitraz required to control them. Eighty male rats, 180 ± 20 g assigned into 4 groups were used for the study. Groups A, B and C were treated daily with an oral dose of 10.0, 2.0 and 0.4 mg/kg body weight of amitraz, while group D was treated with 10 mL/kg water. Parameters evaluated were packed cell volume (PCV), red blood cells (RBCs) counts, reticulocyte counts (RTC), haemoglobin (Hb) concentration, white blood cell (WBC) count and differential white blood cell (DWBC) counts. There was reduction (p < .05) in the mean PCV, RBC, TWBC and Hb of rats in group A four weeks from the start of administration of the amitraz when compared to groups B, C and D. There was dose dependent increase (p < .05) in the mean percentage RTC of rats among groups A, B, C and D between days 56 and 84 of the experiment with group A producing the highest percentage counts. It was concluded that sub-chronic administration of sub-lethal doses of amitraz could lead to regenerative anaemia.