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Access to Indole-Fused Polyheterocycles via Pd-Catalyzed Base-Free Intramolecular Cross Dehydrogenative Coupling
- Cheng, Chao, Chen, Wen-Wen, Xu, Bin, Xu, Ming-Hua
- Journal of organic chemistry 2016 v.81 no.22 pp. 11501-11507
- catalytic activity, chemical reactions, chemical structure, coumarins, organic chemistry, palladium, pyrones, quinolones
- A base-free process to access indole-fused polyheterocycles via a highly efficient and atom-economic palladium-catalyzed intramolecular cross dehydrogenetive coupling (CDC) reaction of 4-aniline substituted coumarins, quinolinones, and pyrones has been developed. A wide range of indolo[3,2-c]coumarins, indolo[3,2-c]quinolinones, and indolo[3,2-c]pyrones can be facilely afforded in good to excellent yields (up to 99%).