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UV Cross-Linkable Graphene/Poly(trimethylene Carbonate) Composites for 3D Printing of Electrically Conductive Scaffolds

Author:
Sayyar, Sepidar, Bjorninen, Miina, Haimi, Suvi, Miettinen, Susanna, Gilmore, Kerry, Grijpma, Dirk, Wallace, Gordon
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.46 pp. 31916-31925
ISSN:
1944-8252
Subject:
biocompatible materials, composite materials, crosslinking, electrical conductivity, electrical treatment, graphene, stem cells, tensile strength, viability
Abstract:
Conductive, flexible graphene/poly(trimethylene carbonate) (PTMC) composites were prepared. Addition of just 3 wt % graphene to PTMC oligomers functionalized with methacrylate end-groups followed by UV cross-linking resulted in more than 100% improvement in tensile strength and enhanced electrical conductivity by orders of magnitude without altering the processability of the host material. The addition of graphene also enhanced mesenchymal stem cell (MSC) attachment and proliferation. When electrical stimulation via the composite material was applied, MSC viability was not compromised, and osteogenic markers were upregulated. Using additive fabrication techniques, the material was processed into multilayer 3D scaffolds which supported MSC attachment. These conducting composites with excellent processability and compatibility with MSCs are promising biomaterials to be used as versatile platforms for biomedical applications.
Agid:
5590137