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Caffeoyl Triterpenoid Esters as Potential Anti-ischemic Stroke Agents from Celastrus orbiculatus
- Li, Jin-Long, Wu, Lei, Wu, Jian, Feng, Hong-Xuan, Wang, Hong-Min, Fu, Yan, Zhang, Ru-Jun, Zhang, Hai-Yan, Zhao, Wei-Min
- Journal of natural products 2016 v.79 no.11 pp. 2774-2779
- Celastrus orbiculatus, X-ray diffraction, bark, bioassays, brain, copper, esters, infarction, neuroprotective effect, rats, spectral analysis, stroke, triterpenoids
- Three new triterpenoids, celastrusins A–C (1–3), together with 3-O-caffeoyl-α-amyrin (4) were isolated from the root bark of Celastrus orbiculatus. Their structures were identified by spectroscopic analysis, X-ray crystallography using Cu Kα radiation, and the comparison of both observed and reported spectroscopic data. An in vitro bioassay revealed that the caffeoyl triterpenoid esters 1, 3, and 4 possess neuroprotective effects against oxygen-glucose deprivation (OGD) induced SH-SY5Y cell damage. Further animal studies indicated that compound 1 significantly reduced brain infarction after transient middle cerebral artery occlusion (MCAO) in rats using a 10 mg/kg (i.v.) dose.