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Micromonohalimanes A and B: Antibacterial Halimane-Type Diterpenoids from a Marine Micromonospora Species
- Zhang, Yan, Adnani, Navid, Braun, Doug R., Ellis, Gregory
A., Barns, Kenneth J., Parker-Nance, Shirley, Guzei, Ilia A., Bugni, Tim S.
- Journal of natural products 2016 v.79 no.11 pp. 2968-2972
- Micromonospora, Symplegma, X-ray diffraction, antibacterial properties, antibiotic resistance, culture media, diterpenoids, genetic traits, methicillin, methicillin-resistant Staphylococcus aureus, spectroscopy
- Despite the fact that actinomycetes harbor the genetic potential to produce terpenes, terpenoid natural products tend to be a rare occurrence in fermentation broths. Here we report two new halimane-type diterpenoids, micromonohalimanes A (1) and B (2), that were isolated from a Micromonospora sp. cultivated from the marine ascidian Symplegma brakenhielmi. This is the first report of the halimane-type diterpenoids from Micromonospora. The structures were determined using spectroscopic methods including X-ray crystallography to establish the absolute configuration. Micromonohalimane B demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus.