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Acetophenone Monomers from Acronychia trifoliolata

Author:
Miyake, Katsunori, Suzuki, Airi, Morita, Chihiro, Goto, Masuo, Newman, David J., O’Keefe, Barry R., Morris-Natschke, Susan L., Lee, Kuo-Hsiung, Nakagawa-Goto, Kyoko
Source:
Journal of natural products 2016 v.79 no.11 pp. 2883-2889
ISSN:
1520-6025
Subject:
Acronychia, anticarcinogenic activity, chemical structure, cytotoxicity, humans, neoplasms, nuclear magnetic resonance spectroscopy
Abstract:
Seven new [acronyculatins I–O (1–7)] and four known acetophenone monomers were isolated from a CH₃OH/CH₂Cl₂ (1:1) extract (N089419) of Acronychia trifoliolata provided by the U.S. National Cancer Institute (NCI, Frederick, MD, USA). Their structures were characterized by using various NMR and HRMS techniques. Among the known compounds, the structure of acronyculatin B (8) was revised. Some of the isolated compounds were evaluated for antiproliferative activity against human cancer cell lines. While most of the tested compounds were not cytotoxic, acronyculatins I (1) and J (2) showed moderate antiproliferative activity.
Agid:
5590308