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Dragmacidins G and H, Bisindole Alkaloids Tethered by a Guanidino Ethylthiopyrazine Moiety, from a Lipastrotethya sp. Marine Sponge
- Hitora, Yuki, Takada, Kentaro, Ise, Yuji, Okada, Shigeru, Matsunaga, Shigeki
- Journal of natural products 2016 v.79 no.11 pp. 2973-2976
- Porifera, alkaloids, cytotoxicity, high performance liquid chromatography, nuclear magnetic resonance spectroscopy
- LCMS analysis of the extract and a cytotoxicity assay of the HPLC fractions generated from a small-scale extract of a Lipastrotethya sp. marine sponge demonstrated the presence of bisindole alkaloids that were associated with the cytotoxic activity. Two bisindole alkaloids tethered by a guanidino ethylthiopyrazine moiety, dragmacidins G (1) and H (2), were isolated, and their structures were assigned by analysis of the MS and NMR data. They showed moderate cytotoxic activity against HeLa cells.