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α-Glucosidase Inhibitors from the Marine-Derived Fungus Aspergillus flavipes HN4-13

Author:
Wang, Cong, Guo, Lei, Hao, Jiejie, Wang, Liping, Zhu, Weiming
Source:
Journal of natural products 2016 v.79 no.11 pp. 2977-2981
ISSN:
1520-6025
Subject:
Aspergillus flavipes, acarbose, alpha-glucosidase, deoxynojirimycin, fungi, inhibitory concentration 50, sediments, spectral analysis
Abstract:
Three new butenolide derivatives, flavipesolides A–C (1–3), along with 13 known compounds (4–13, aspulvinone Q, monochlorosulochrin, and dihydrogeodin), were isolated from the marine-derived Aspergillus flavipes HN4-13 from a Lianyungang coastal sediment sample. The structures were elucidated by spectroscopic evidence. Compounds 4–6 and 9 were noncompetitive α-glucosidase inhibitors with Kᵢ/IC₅₀ values of 0.43/34, 2.1/37, 0.79/19, and 2.8/90 μM, respectively. Compounds 1–3, 8, 10, and 13 are mixed α-glucosidase inhibitors with Kᵢ/IC₅₀ values of (2.5, 19)/44, (3.4, 14)/57, (9.2, 4.7)/95, (6.3, 5.5)/55, (1.4, 0.60)/9.9, and (2.5, 7.2)/33 μM, respectively (IC₅₀ 101 μM for acarbose and 79 μM for 1-deoxynojirimycin).
Agid:
5590315