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Graphene Oxide Directed One-Step Synthesis of Flowerlike Graphene@HKUST-1 for Enzyme-Free Detection of Hydrogen Peroxide in Biological Samples

Wang, Qingxiang, Yang, Yizhen, Gao, Feng, Ni, Jiancong, Zhang, Yanhui, Lin, Zhenyu
ACS Applied Materials & Interfaces 2016 v.8 no.47 pp. 32477-32487
blood serum, coordination polymers, copper, electrochemistry, graphene, graphene oxide, humans, hydrogen peroxide, nanocomposites, nitrates, raw materials, surface area
A novel metal–organic framework (MOF)-based electroactive nanocomposite containing graphene fragments and HKUST-1 was synthesized via a facile one-step solvothermal method using graphene oxide (GO), benzene-1,3,5-tricarboxylic acid (BTC), and copper nitrate (Cu(NO₃)₂) as the raw materials. The morphology and structure characterization revealed that the GO could induce the transformation of HKUST-1 from octahedral structure to the hierarchical flower shape as an effective structure-directing agent. Also, it is interesting to find out that the GO was torn into small fragments to participate in the formation of HKUST-1 and then transformed into the reduction form during the solvothermal reaction process, which dramatically increased the surface area, electronic conductivity, and redox-activity of the material. Electrochemical assays showed that the synergy of graphene and HKUST-1 in the nanocomposite leaded to high electrocatalysis, fast response, and excellent selectivity toward the reduction of hydrogen peroxide (H₂O₂). Based on these remarkable advantages, satisfactory results were obtained when the nanocomposite was used as a sensing material for electrochemical determination of H₂O₂ in the complex biological samples such as human serum and living Raw 264.7 cell fluids.