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Increased risk of hepatitis E virus infection in schizophrenia

Xue, Yong, Sun, Xiaohua, Li, Yinghui, Liu, Xin, Dong, Chen
Archives of virology 2013 v.158 no.2 pp. 359-365
Orthohepevirus A, risk, immunoglobulin G, immunoglobulin M, seroprevalence, genotype, patients, interleukin-10, RNA, interleukin-4, interleukin-12
Until now, the risk of HEV infection in schizophrenia was unknown. The present results showed that the seroprevalence of anti-HEV IgG and anti-HEV IgM in schizophrenia were significantly higher than that in healthy controls. Anti-HEV IgG positivity increased with age and with the duration of disease in schizophrenia patients. Moreover, schizophrenia patients with increased CD4⁺/CD8⁺ T-cell ratios (>2.03) had higher anti-HEV IgG detection rates than those with normal ratios (1.05-2.03). Compared with the schizophrenia patients who tested anti-HEV IgG negative, the levels of interleukin-4 and interleukin-10 (Th2 cytokines) were significantly higher, while the interleukin-12 (Th1 cytokine) level was significantly lower, in those with anti-HEV IgG positivity. Of five schizophrenia patients who were anti-HEV IgM positive, four had elevated CD4⁺/CD8⁺ T-cell ratios. HEV RNA was isolated from one of these four patients and classified as genotype 4. Anti-HEV IgM positivity was not detected among healthy controls. Therefore, schizophrenia patients exhibited a higher risk of HEV infection than controls.