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Two new triterpenoids and a new naphthoquinone derivative isolated from a hard coral-derived fungus Scopulariopsis sp.

Author:
Elnaggar, Mohamed S., Ebada, Sherif S., Ashour, Mohamed L., Ebrahim, Weaam, Singab, Abdelnasser, Lin, Wenhan, Liu, Zhen, Proksch, Peter
Source:
Fitoterapia 2017 v.116 pp. 126-130
ISSN:
0367-326X
Subject:
Scopulariopsis, corals, cytotoxicity, fungi, navy beans, nitrogen compounds, nuclear magnetic resonance spectroscopy, polyketides, sesquiterpenoids, triterpenoids, Red Sea
Abstract:
Scopulariopsis sp. isolated from the Red Sea hard coral Stylophora sp. yielded two new triterpenoids (1–2) and a new naphthoquinone derivative (8) when cultured on white beans. In addition, fourteen known compounds including three triterpene analogues (3–5), two sesquiterpenoids (6–7), two polyketides (9–10) and seven nitrogenous compounds (11–17) were isolated. All structures were determined through extensive analysis of the NMR and MS data as well as by comparison with literature data. All isolated compounds were evaluated for their cytotoxic, antibacterial and antitubercular activities. However, none of them showed significant activity.
Agid:
5598019