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Megastigmane glycosides from leaves of Eucommia ulmoides Oliver with ACE inhibitory activity
- Yan, Jian-Kun, Ding, Li-Qin, Shi, Xu-Liu, Donkor, Paul Owusu, Chen, Li-Xia, Qiu, Feng
- Fitoterapia 2017 v.116 pp. 121-125
- Eucommia ulmoides, antihypertensive effect, glycosides, high performance liquid chromatography, leaves, peptidyl-dipeptidase A
- Four new megastigmane glycosides, eucomegastigsides A-D (2, 3, 5 and 7), together with three known megastigmane glycosides, (6R, 7E, 9R)-9-hydroxy-4, 7-megastigmadien-3-one-9-O-[α-l-arabinopyranosyl-(l→6)-β-d-glucopyranoside (1), foliasalacioside B1 (4) and eleganoside A (6), were isolated from the leaves of Eucommia ulmoides Oliver. Their anti-hypertensive effect was investigated in vitro based on the inhibition of Angiotensin Converting Enzyme (ACE) using HPLC. The results showed that the isolates (2, 3, 4, 5, 7) had moderate inhibitory effects on ACE in vitro compared with captopril.