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Role and inhibition of Src signaling in the progression of liver cancer

Ren, Hong, Fang, Jie, Ding, Xianjun, Chen, Qiyun
Open life sciences 2016 v.11 no.1 pp. 513-518
Hepatitis C virus, cell death, death, developing countries, hepatitis B, liver neoplasms, men, microRNA, physiological state
During 2012, about 782,500 new liver cancer cases were diagnosed and 745,500 deaths occurred all around the world. Liver cancer is the 2nd major cause of cancer death in men around the world and in underdeveloped countries. Dysregulation of the balance between proliferation and cell death, hepatitis B virus infection and hepatitis C virus chronic infection, and carcinogenic micro RNAs mainly contribute to the development and progression of liver cancer. Under physiological status, Src maintained the foundation of cells. While in liver cancer, it is known that the basic activities of cells are apparently disturbed possibly by Src. The mechanisms underlying the development and progression of liver cancer is needed to elucidate. In this study, we summarized newly found regulation pathway of SRC signaling, and clinical experience with inhibitors of Src signaling, such as, novel molecules that directly or indirectly targeted Src signaling which can be utilized in the treatment of liver cancer.