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Cytotoxic pimarane-type diterpenes from the marine sediment-derived fungus Eutypella sp. FS46

Author:
Liu, Hongxin, Zhang, Ling, Chen, Yuchan, Li, Saini, Tan, Guohui, Sun, Zhanghua, Pan, Qingling, Ye, Wei, Li, Haohua, Zhang, Weimin
Source:
Natural product research 2017 v.31 no.4 pp. 404-410
ISSN:
1478-6427
Subject:
Eutypella, culture media, cytotoxicity, diterpenoids, fungi, neoplasm cells, spectroscopy, South China Sea
Abstract:
Two new pimarane-type diterpenes, scopararanes H-I (1 – 2), along with five known ones (3 – 7) were isolated from the culture broth of a marine sediment-derived fungus Eutypella sp. FS46, which was obtained from the South China Sea. Their structures were established by extensive spectroscopic analysis. All of them were evaluated for their cytotoxic activities against MCF-7, NCI-H460 and SF-268 tumour cell lines. Scopararane I (2) showed moderate inhibitory activities.
Agid:
5607385