Palladium-Catalyzed Acylations: One-Pot Synthesis of Indenones
- Source:
- Journal of organic chemistry 2017 v.82 no.1 pp. 372-381
- ISSN:
- 1520-6904
- Subject:
- acylation, aldehydes, catalytic activity, chemical structure, condensation reactions, lignans, organic chemistry, palladium, synthesis
- Abstract:
- An efficient, one-pot synthesis of substituted indenones was accomplished starting from simple o-iodoketones and aldehydes. [Pd]-catalyzed direct acylation of o-iodoketones with aldehydes was employed as the key step. Subsequent intramolecular aldol condensation afforded the indenones. Notably, a variety of indenones were achieved. Significantly, the natural product neolignan was accomplished in one pot.
- Agid:
- 5607573
- https://doi.org/10.1021/acs.joc.6b02453