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PB@Au Core–Satellite Multifunctional Nanotheranostics for Magnetic Resonance and Computed Tomography Imaging in Vivo and Synergetic Photothermal and Radiosensitive Therapy

Dou, Yan, Li, Xue, Yang, Weitao, Guo, Yanyan, Wu, Menglin, Liu, Yajuan, Li, Xiaodong, Zhang, Xuening, Chang, Jin
ACS Applied Materials & Interfaces 2017 v.9 no.2 pp. 1263-1272
biocompatibility, computed tomography, image analysis, in vivo studies, intravenous injection, mice, nanogold, nanoparticles, therapeutics, toxicity
To integrate multiple diagnostic and therapeutic strategies on a single particle through simple and effective methods is still challenging for nanotheranostics. Herein, we develop multifunctional nanotheranostic PB@Au core–satellite nanoparticles (CSNPs) based on Prussian blue nanoparticles (PBNPs) and gold nanoparticles (AuNPs), which are two kinds of intrinsic theranostic nanomaterials, for magnetic resonance (MR)–computed tomography (CT) imaging and synergistic photothermal and radiosensitive therapy (PTT–RT). PBNPs as cores enable T₁- and T₂-weighted MR contrast and strong photothermal effect, while AuNPs as satellites offer CT enhancement and radiosensitization. As revealed by both MR and CT imaging, CSNPs realized efficient tumor localization by passively targeted accumulation after intravenous injection. In vivo studies showed that CSNPs resulted in synergistic PTT–RT action to achieve almost entirely suppression of tumor growth without observable recurrence. Moreover, no obvious systemic toxicity of mice confirmed good biocompatibility of CSNPs. These results raise new possibilities for clinical nanotheranostics with multimodal diagnostic and therapeutic coalescent design.