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A beginner’s guide to tissue clearing
- Ariel, Pablo
- The international journal of biochemistry & cell biology 2017 v.84 pp. 35-39
- cell proliferation, image analysis, sampling, tissue analysis, tissue culture, tissues
- The last decade has seen a proliferation of tissue clearing methods that render large biological samples transparent and allow unprecedented three-dimensional views of enormous volumes of tissue. For a scientist wondering whether these methods will be useful to address their research problems, it can be bewildering to sort through the ever-increasing number of papers introducing new clearing methods. Here, I provide a concise summary for the novice describing what tissue clearing is, which research problems it can be applied to, how to decide on a clearing method, and where the field is headed in the future.