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Furofuran lignan glucosides from the leaves of Vitex negundo var. cannabifolia

Author:
Li, Yue-Ting, Li, Man-Man, Sun, Jing, Zhu, Zhi-Xiang, Song, Yue-Lin, Pang, Dao-Ran, Zheng, Jiao, Zhao, Yun-Fang, Tu, Peng-Fei, Li, Jun
Source:
Natural product research 2017 v.31 no.8 pp. 918-924
ISSN:
1478-6427
Subject:
Vitex negundo, glucosides, inhibitory concentration 50, leaves, lignans, nitric oxide, spectral analysis, spectroscopy
Abstract:
Two new furofuran lignan glucosides, cannabilignin (1) and isocannabilignin (2), together with four known compounds (3 – 6), were isolated from the leaves of Vitex negundo var. cannabifolia . The structures of the isolates were elucidated by analysis of spectroscopic data. Compound 3 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC ₅₀ value of 69.1 ± 5.8 μM.
Agid:
5616086