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Silver-catalyzed one-pot synthesis of benzyl 2-alkynoates under ambient pressure of CO2 and ligand-free conditions

Author:
Guo, Fang-Jie, Zhang, Zhi-Zhi, Wang, Jing-Yun, Sun, Jing, Fang, Xiang-Chen, Zhou, Ming-Dong
Source:
Tetrahedron 2017 v.73 pp. 900-906
ISSN:
0040-4020
Subject:
acetonitrile, alkynes, carbon dioxide, catalysts, chemical reactions, chemical structure, iodides, silver, synthesis
Abstract:
The carboxylative coupling of aryl/alkyl terminal alkynes, CO2 and benzyl halides was investigated using silver iodide as the catalyst and Cs2CO3 as the base in CH3CN under ligand-free conditions. This reaction protocol shows a wide substrate scope and high functional group tolerance ability for benzyl halides, in which various functionalized benzyl 2-alkynoates were achieved in good yields. This one-pot, ligand-free and CH3CN mediated reaction proved to be easy to handle and could be facilitated under atmospheric CO2 pressure.
Agid:
5617580